13 of Our Favorite Sciencey 'Big Bang Theory' Guest Stars

Mar. 16, 2025

01of 13Stan LeeCliff Lipson/CBSThe comic book creator — who famously had cameos in many of his own movies — played himself

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Stan Lee

Cliff Lipson/CBS

THE BIG BANG THEORY Stan Lee

The comic book creator — who famously had cameos in many of his own movies — played himself

02of 13Bill GatesErik Voake/CBSGates made his cameo in season 11, spending the day at Penny’s company — much to the surprise of her pals. Leonard inserts himself, though, finding Gates at his hotel and introducing himself, ruining a surprise Penny planned for him in the process. And Sheldon thinks the entire meeting is a prank, given its April 1 timing (it’s not!).

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Bill Gates

Erik Voake/CBS

THE BIG BANG THEORY Bill Gates

Gates made his cameo in season 11, spending the day at Penny’s company — much to the surprise of her pals. Leonard inserts himself, though, finding Gates at his hotel and introducing himself, ruining a surprise Penny planned for him in the process. And Sheldon thinks the entire meeting is a prank, given its April 1 timing (it’s not!).

03of 13Bill NyeMichael Yarish/Warner Bros. EntertainmentThe Science Guy himself came on to the show in season 7 (and again in season 12), when Sheldon brought him in to get revenge on Professor Proton (Bob Newhart). Another restraining order ensued.

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Bill Nye

Michael Yarish/Warner Bros. Entertainment

THE BIG BANG THEORY Bill Nye

The Science Guy himself came on to the show in season 7 (and again in season 12), when Sheldon brought him in to get revenge on Professor Proton (Bob Newhart). Another restraining order ensued.

04of 13Bob NewhartDarren Michaels/Warner Bros. Entertainment Inc.So no, he’s not a scientist, but the beloved actor appeared on six episodes of the show playing the guys' childhood icon, Professor Proton. The role earned him three Emmy nominations and one win.

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Bob Newhart

Darren Michaels/Warner Bros. Entertainment Inc.

THE BIG BANG THEORY Bob Newhart

So no, he’s not a scientist, but the beloved actor appeared on six episodes of the show playing the guys' childhood icon, Professor Proton. The role earned him three Emmy nominations and one win.

05of 13Buzz AldrinBuzz Aldrin onThe Big Bang Theory.Monty Brinton/CBSIn season 6, the iconic astronaut appeared in the form of a video showing him handing out Milky Way and Mars bars on Halloween — and talking up his storied career to kids.

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Buzz Aldrin

Buzz Aldrin onThe Big Bang Theory.Monty Brinton/CBS

THE BIG BANG THEORY Buzz Aldrin

In season 6, the iconic astronaut appeared in the form of a video showing him handing out Milky Way and Mars bars on Halloween — and talking up his storied career to kids.

06of 13Carrie FisherRobert Voets/CBSOne of severalStar Warsguests, Fisher appeared briefly in season 7, when Sheldon and his new friend James Earl Jones ding dong ditched her.

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Carrie Fisher

Robert Voets/CBS

THE BIG BANG THEORY CARRIE FISHER

One of severalStar Warsguests, Fisher appeared briefly in season 7, when Sheldon and his new friend James Earl Jones ding dong ditched her.

07of 13James Earl JonesRobert Voets/CBSYou read that right — new friends with Sheldon. The two bond over their love ofStar Warsin the season 7 episode, and have dinner together before getting wrapped up in all sorts of antics.

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James Earl Jones

THE BIG BANG THEORY James Earl Jones

You read that right — new friends with Sheldon. The two bond over their love ofStar Warsin the season 7 episode, and have dinner together before getting wrapped up in all sorts of antics.

08of 13Elon MuskMonty Brinton/CBSThe Tesla founder was a guest in season 9, volunteering at a soup kitchen on Thanksgiving with Howard. He later had a cameo on an episode of theBig Bangspin-off,Young Sheldon.

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Elon Musk

Monty Brinton/CBS

THE BIG BANG THEORY ELAN

The Tesla founder was a guest in season 9, volunteering at a soup kitchen on Thanksgiving with Howard. He later had a cameo on an episode of theBig Bangspin-off,Young Sheldon.

09of 13Mark HamillMark Hamill.Michael Yarish/CBSLuke Skywalker had a very important guest role onTBBT,serving as officiant for Sheldon and Amy’s season 11-ending wedding. He got roped into the task after Howard found his lost dog and he offered him a favor as thanks.

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Mark Hamill

Mark Hamill.Michael Yarish/CBS

THE BIG BANG THEORY Mark Hamill

Luke Skywalker had a very important guest role onTBBT,serving as officiant for Sheldon and Amy’s season 11-ending wedding. He got roped into the task after Howard found his lost dog and he offered him a favor as thanks.

10of 13George TakeiCliff Lipson/CBSOntoStar Trek! Takei popped up in season 4, offering Howard some romantic advice during a fantasy sequence. (His costar Leonard Nimoy appeared in season 5, voicing his own action figure, and Nimoy’s son had a bit part in season 9).

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George Takei

THE BIG BANG THEORY George Takei

OntoStar Trek! Takei popped up in season 4, offering Howard some romantic advice during a fantasy sequence. (His costar Leonard Nimoy appeared in season 5, voicing his own action figure, and Nimoy’s son had a bit part in season 9).

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LeVar Burton

THE BIG BANG THEORY LeVar Burton

12of 13Neil deGrasse TysonMichael Yarish/Warner Bros. Entertainment Inc.In season 4, Tyson, chummy with Raj, engaged in a war of words with Sheldon over the demotion of Pluto as a planet. He surfaced again briefly in a season 12 episode, too.

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Neil deGrasse Tyson

Michael Yarish/Warner Bros. Entertainment Inc.

THE BIG BANG THEORY Neil deGrasse Tyson

In season 4, Tyson, chummy with Raj, engaged in a war of words with Sheldon over the demotion of Pluto as a planet. He surfaced again briefly in a season 12 episode, too.

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Stephen Hawking

Sonja Flemming/CBS

THE BIG BANG THEORY Stephen Hawking

source: people.com